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Smoking as well as hypertension, dyslipidemia, diabetes, obesity, aging, lack of exercise, excessive salt intake, and menopause are known to induce endothelial dysfunction [7]

For this analysis, the mobile phase gradient started at 20% and was maintained for 1 min

They also observed that melittin inhibits NF-B transcription in TNF-induced liver injury

Exposure to low dose of ionizing radiation was found to suppress cancer cell proliferation via suppressing p38 kinase in MCF-7 human breast cancer cells [103], inhibiting JNK as well as ERK phosphorylation [87], and down-regulating NF-B through suppressing TNF-induced degradation of inhibitor of kappa B (IB) protein and release of p65 subunit to the nucleus, reducing NF-B activity [104]